TTPA and open-angle glaucoma: Furthermore, the AA genotype for the rs6994076 polymorphism in the TTPA gene was significantly (after correction for multiple testing) associated with lower plasma levels of vitamin E. However, the rs737723 polymorphism in the SEC14L2/TAP, which presented a significant association with POAG risk (after correction for multiple testing), was not significantly associated with lower plasma vitamin E concentrations in the whole population.