SLC23A2 and open-angle glaucoma: These results and their effects on POAG risk are also consistent with other studies performed on mice demonstrating that low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2 [50] (or also that an increase in the expression of the SVCT2 gene in the mouse model) raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage [51].