Cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1) and myocilin, trabecular meshwork inducible glucocorticoid response (MYOC) mutations were identified in early-onset glaucoma in humans, whereas mutations in the CYP1B1 and FOXC1 were detected in mice with early-onset glaucoma. Here, MYOC is linked to Onset.