The results of our study concerning the researches on lipid metabolism, the proinflammatory activity of plasma, and coagulation parameters have shown that type 2 diabetes mellitus registers a significant frequency in cumulating the main factors of vascular and atherosclerotic risk, the umoral dyslipidemic syndrome (which is characterized by the LDLc increase and HDLc decrease), and the increase in inflammatory markers (IL-1 beta), age, and duration of diabetes, encouraging the increased risk for thrombotic events with lethal potential (increase of vWF, PAI-1, decrease of PC). This evidence concerns the gene SERPINE1 and type 2 diabetes mellitus.