SERPINE1 and cardiovascular disorder: Hemostasis abnormalities revealed by our study include the increased values of von Willebrand Factor and PAI-1 and decreased levels of protein C. Taking into account the fact that a significant modification of the plasmatic levels of protein C, von Willebrand Factor and PAI-1 could be identified at diabetic patients without clinically manifest cardiovascular diseases, these modifications with prothrombotic potential have been considered to precede the thrombotic complications, having a predictive role for such complications.