Tau pathology, in the form of neurofibrillary tangles, neuropil threads, and abnormal neurites, corresponded to Braak and Braak stage V. Overall, there was a high level of Alzheimer's pathology (A3, B3, and C3) according to the recently published consensus criteria, confirming a diagnosis of Alzheimer's disease (AD).2 A small number of leptomeningeal and cortical vessels showed patchy Aβ deposition. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.