MTOR and diabetic kidney disease: However, other pathways known to be involved in the pathogenesis of diabetic nephropathy through intracellular stress induced-autophagy (such as AMPK and mTOR activity, hypoxia and ER stress; Fogo, 2011; Godel et al, 2011; He et al, 2010; Inoki et al, 2011; Kume et al, 2010, 2012; Nath, 2010) were not affected in our models (Supporting Information Fig S15A–C).