HOXB7 expression appeared tightly regulated in normal human melanocytes and constitutively activated in melanomas.8 In addition Wu and coauthors demonstrated that breast cancer cell lines, transfected with HOXB7 start to display many features related to EMT, such as loss of expression of adhesion molecules and changes in cell morphology and cytoskeletal arrangement.27 Concordantly, other recent findings suggested HOXB7 could be a valuable prognostic factor in colorectal cancer28 and oral squamous cell carcinoma.29 This evidence concerns the gene HOXB7 and breast cancer.