These include HOXA5 and HOXA10, playing tumor suppressor functions in breast carcinoma, or HOXC11 inducing S100β, an established marker of melanoma progression.4–6 HOXB7 has been reported as a master regulator in the oncogenic hierarchy.7 HOX proteins bind to DNA through a highly conserved 60 amino acid sequence called the homeodomain. This evidence concerns the gene HOXB7 and melanoma.