6 Marx Marx AH AH Burandt Burandt EC EC Choschzick Choschzick M M Heterogenous high-level HER-2 amplification in a small subset of colorectal cancers Heterogenous high-level HER-2 amplification in a small subset of colorectal cancers Hum Pathol. The gene discussed is ERBB2; the disease is colorectal cancer.