HSP90AB1 and cancer: Therefore, due to cancer cell dependence upon specific -oncogenic- Hsp90 protein clients, Hsp90 inhibition is thought to negatively interfere with critical oncogenic signaling pathways involved in the hallmark traits of cancer (i.e. sustaining cell proliferation, resisting cell death, and promoting invasion and metastasis)[9], demonstrating exciting prospects in the future of cancer therapeutics[10].