BIRC5 and cancer: To date, several mechanisms have been proposed to explain the anti-cancer effects of jasmonates, including induction of severe ATP depletion via mitochondrial perturbation[33], induction of re-differentiation via mitogen-activated protein kinase activity[31], induction of a significant decrease in survivin levels via the β-catenin/T-cell factor pathway[27], and induction of apoptosis via pro-apoptotic proteins of the Bcl-2 family[34], opening the mitochondrial permeability transition pore complex[11] and activation of extrinsic apoptotic pathway[35].