Since our findings indicated that sub-cytotoxic MJ abolished the VEGF expression in gastric cancer cells, combining the evidence that restoration of VEGF expression through MMP-14 over-expression rescued the decrease in tube formation of endothelial cells, we believe that the decreased expression of MMP-14 and downstream VEGF, at least in part, contributes to the anti-angiogenic function of sub-cytotoxic MJ in gastric cancer cells. This evidence concerns the gene VEGFA and gastric cancer.