EGFRBi aATC: 1) can efficiently kill tumor cells; 2) EGFRBi aATC may disable the COX2 and PGE2 mediated suppression of CTLs, Th1, and NK cells by modulating immune suppressive microenvironment to immune activating Th1 microenvironment. The gene discussed is PTGS2; the disease is neoplasm.