Recently, we reported that tumor spheres formed by breast cancer cells were visibly smaller in size in a Th1 enriched microenvironment, differentiation of granulocytic CD14−/HLA-DR−/CD11b+/CD33+ and monocytic CD14+/HLA-DR−/CD11b+/CD33+ MDSC populations was reduced with further reduction and attenuation of their suppressive activity in the presence of aATC [14]. The gene discussed is ITGAM; the disease is breast cancer.