Recently, we reported that tumor spheres formed by breast cancer cells were visibly smaller in size in a Th1 enriched microenvironment, differentiation of granulocytic CD14−/HLA-DR−/CD11b+/CD33+ and monocytic CD14+/HLA-DR−/CD11b+/CD33+ MDSC populations was reduced with further reduction and attenuation of their suppressive activity in the presence of aATC [14]. This evidence concerns the gene CD33 and breast cancer.