AKI also leads to coagulation abnormalities and increased incidence of sepsis with multi-organ failure as well as to upregulation of cytokines (interleukin-1, interleukin-6, tumor necrosis factor-α) and/or immune-mediated major organ dysfunction (i.e. heart, lungs, and brain) [38,39]. The gene discussed is IL6; the disease is acute kidney injury.