While both beneficial and detrimental roles are not mutually exclusive, support for an overriding detrimental role for CD88 has been provided by the improvement in pathology and clinical symptoms obtained in animals models of AD, Huntington’s disease (HD) and ALS treated with specific antagonists for this receptor (PMX53 and PMX205)[25-27], as well as in ischemic stroke[11]. Here, C5AR1 is linked to amyotrophic lateral sclerosis.