Immunofluorescent double labeling of C5L2 with early (AT8) (Figure5A) or mature (PHF-1) (data not shown) tangle markers confirmed co-localization of C5L2 with phosphorylated tau in structures which morphologically appeared to be NFTs, DNPs or NTs in frontal cortex and hippocampus in the AD brain. Here, C5AR2 is linked to Alzheimer disease.