MAPT and Alzheimer disease: Immunofluorescent double labeling of C5L2 with early (AT8) (Figure5A) or mature (PHF-1) (data not shown) tangle markers confirmed co-localization of C5L2 with phosphorylated tau in structures which morphologically appeared to be NFTs, DNPs or NTs in frontal cortex and hippocampus in the AD brain.