Guo et al. demonstrated that TLR4 D229G and T399I SNPs that are associated with protection from hepatic fibrosis reduce TLR4-mediated inflammatory and fibrogenic signalling, and lower the apoptotic threshold of activated hepatic stellate cells (HSCs) [192], thus suggesting a critical role of TLR4 signalling in regulating HSCs activation. This evidence concerns the gene TLR4 and Hepatic fibrosis.