PNPLA3 and hepatocellular carcinoma: The rs738409 PNPLA3 genotype also influences steatosis development in chronic hepatitis C patients and is independently associated with cirrhosis and other steatosis-related clinical outcomes, such as lack of response to antiviral treatment and possibly hepatocarcinoma [63-66], and with of cirrhosis and hepatocellular carcinoma in patients with alcohol abuse [59, 67-71].