We evaluated whether the LPIN1 rs13412852 C>T polymorphism was associated with NASH and fibrosis in pediatric Italian patients with NAFLD, finding that the TT genotype was under-represented in pediatric but not in adult patients with NAFLD, was associated with less severe dysplipidemia, and that children with this genotype had a trend for a lower prevalence of NASH and significantly less severe liver damage independently of PNPLA3 genotype and other risk factors [94]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatohepatitis.