Moreover, analysis of the combined UK and Italian groups identified the presence of wild-type KLF6 as a predictor of moderate/advanced fibrosis independently of all other risk factors of progressive disease, suggesting that the wild-type KLF6 genotype is a significant susceptibility factor for fibrotic NAFLD, whereas KLF6 IVS1-27G>A protects against the development of fibrosis [12]. Here, KLF6 is linked to metabolic dysfunction-associated steatotic liver disease.