PNPLA3 and liver disorder: A more recent GWAS conducted in a larger population was able to identify a wider set of genetic variants influencing steatosis besides I148M of PNPLA3 [273], of whom the rs2854116 SNP of Glucokinase regulator (GCKR), involved in the regulation of the uptake of monosaccharides and lipogenesis was confirmed to predispose to fatty liver and dyslipidemia in obese children and adolescents independently of PNPLA3 [75], although the effect on histological progression of liver disease is still unknown, especially in view of the ameliorating effect on insulin resistance.