Interestingly enough, Petta et al. have recently reported that in 160 consecutive patients with biopsy-proven NAFLD, the IL28B rs12979860 CC genotype was not associated with protection from steatosis in the absence of viral infection, but it was associated with about a four-fold increased risk of moderate-severe lobular inflammation independently of age, gender, triglycerides, hyperuricemia, and steatosis grade, and was significantly associated with severe fibrosis (stage 3-4) at univariate analysis [238]. The gene discussed is IFNL3; the disease is steatosis.