Several papers have reported a significant decrease in the serum levels of adiponectin in NASH patients [147, 148], and the overall evidence support the existence of an inverse relationship between adiponectin levels and the severity of NAFLD [149-151], suggesting a role for adiponectin dysregulation in the pathogenesis of NASH [149]. This evidence concerns the gene ADIPOQ and metabolic dysfunction-associated steatohepatitis.