Provided that the association between IL28B genotype and hepatic inflammation complicating NAFLD is confirmed in larger series that are urgently awaited, data would suggest that the IL28B CC genotype represent a host factor influencing hepatic inflammation in different liver diseases, and the incorporation together with PNPLA3 in non-invasive scores could be useful to refine the risk of NASH. Here, PNPLA3 is linked to metabolic dysfunction-associated steatohepatitis.