Interestingly however, the rs12979860 CC genotype protected form steatosis in patients positive, but not in those negative for the PNPLA3 G variant at risk, suggesting that an interaction occurs between IL28B and PNPLA3 genotypes in the pathogenesis of steatosis in CHC non genotype-3 patients. Here, PNPLA3 is linked to cryohydrocytosis.