On the other hand, the CYP4A gene cluster has been shown to affect renal injury in male congenic Dhal S rats introgressed with the chromosome 5 CYP4A region of Lewis rats [27] and Edn2 has been implicated in feline naturally occurring renal failure [28] and in development of glomerulosclerosis in transgenic rats expressing the human Edn2 [29], thus both genes could be candidates that might underlie the effect of GIS-pm3 on hypertensive nephrosclerosis as represented in GIS measures. Here, EDN2 is linked to Renal insufficiency.