By contrast, the expression of GPR55 was increased by the HF treatment, with no additional effects of LPS or HU210, whereas the expression of PPARγ was not affected by the treatments (Figure S5Nonetheless, an important finding was that fat ingestion during chronic CB receptor stimulation exacerbated glucose intolerance and completely abrogated the glucose-induced insulin levels that were observed after the HF diet (Figure 5C), possibly explaining the worsened glucose intolerance that was observed. The gene discussed is PPARG; the disease is Glucose intolerance.