The relevance of this phenomenon in cancer has been shown for the genes MMP13, Birch2, and Birch3, which are functionally related oncogenes contained on the same amplification in osteosarcoma [28], and for BIRC2 and YAP1, cooperating oncogenes in an amplification in hepatocellular carcinomas [8]. The gene discussed is MMP13; the disease is hepatocellular carcinoma.