We found that AF-6 increases the amount of PINK1/parkin-mediated mitophagy, as shown by the lower number of mitochondria in cells co-transfected with AF-6 when compared with cells co-transfected with control LacZ, as assessed by the mitochondrial marker Tom-20 (Fig. 7A and B). This evidence concerns the gene TOMM20 and atrial fibrillation.