For instance, CCR5 is a G-protein-coupled seven-transmembrane receptor expressed in different cell types like T cells, macrophages, dendritic cells and microglia, and that binds to several chemokines, including: CCL3 (MIP-1alpha/Macrophage Inflammatory Protein b-chemokine), CCL4 (MIP- 1beta), CCL5 (RANTES), CCL8 (MCP-2), CCL11 (eotaxin), CCL14 (HCC-1), CCL16 (HCC-4) [14]. The gene discussed is CCL16; the disease is hepatocellular carcinoma.