EPB41L5 and malignant colon neoplasm: Interestingly, some aspects of the mutant phenotype of foscrbY10A;crbGX24 embryos, such as un-coordinated apical constriction, resemble those described for human colon cancer epithelial DLD-1 cells upon RNAi-mediated knock-down of Lulu, the mammalian ortholog of Yurt.