While a recent study showed ZnT8-specific IFN-γ-producing CD4+ T cells were present in healthy adults at a lower frequency than in type 1 diabetes patients [21], we were intrigued by the fact that ZnT8 peptides induced strong IP-10 secretion in 5 out of 10 healthy donors (Table 2). The gene discussed is CXCL10; the disease is type 1 diabetes mellitus.