KIT and acute myeloid leukemia: Because c-kit proto-oncogene and bcl-2 anti-apoptotic gene appear to be abnormal activation and closely related to apoptosis, cell cycle and proliferation in AE-positive AML cells [19]–[21], we detected the effects of C646 on protein and mRNA levels of c-kit and bcl-2 by Western blot and qRT-PCR, respectively.