We showed that mice deficient for Hamp (Hamp−/−) were significantly more susceptible to infection than mice carrying one (Hamp+/−) or two (Hamp+/+) (Mantel-Cox test P = 0.0079) wild type allele at Hamp. These results confirm the importance of Hamp during acute systemic model of Salmonella Typhimurium infection. The gene discussed is HAMP; the disease is infection.