The most common ETS rearrangement is the translocation of the androgen-regulated transmembrane protease serine 2 (TMPRSS2) gene, with the v-ets erythroblastosis virus E26 oncogene homolog gene (ERG) transcription factor accounting for about 85% of all ETS rearrangement-positive prostate cancers [2]–[4]. The gene discussed is ERG; the disease is Familial prostate cancer.