POU5F1 and cancer: Moreover, miR-145 inhibits cell growth by targeting c-Myc and IRS-1 [25], suppresses the pluripotent potential of embryonic and cancer stem cells by targeting OCT4, SOX2 and NANOG [26], [27] and regulates cell migration, invasion and metastasis by targeting ADAM17 [28], mucin1 [29], FSCN1 [30].