SLC5A2 and diabetes mellitus: We and others have explored the effects of SGLT2 blockade on the altered sodium handling seen in diabetes, which is known to contribute to both hypertension and glomerular hyperfiltration [12], [21] but the important question that remains to be resolved is whether SGLT2inh have additional renal benefits (beyond serum glucose lowering) by blocking excess glucose entry into the proximal tubule cells under diabetic conditions.