The contribution of the intracellular enzyme CANP-2 to the degradation of MBP in vivo may be explained considering that in course of MS, activated astrocytes can undergo apoptosis [39], [40] and this would allow to CANP-2 to be released and come in contact with MBP produced by oligodendrocytes. The gene discussed is CAPN2; the disease is myeloid sarcoma.