TGFB1 and cancer: As deregulation of the TGF-β pathway underlies tumor suppression in normal epithelia tissue and TGF-β activation within tumors promotes epithelial-to-mesenchymal transition (EMT) and metastasis, the identification by our studies that these miRNAs are direct targets of the TGF-β pathway provides a previously unknown link suggesting that they are downstream mediators of this pathway in carcinogenesis and cancer progression.