The association between classical CVD risk phenotypes (hypertension, obesity and lipid status) and the four widely investigated CVD candidate gene polymorphisms was tested: ACE I/D, APOE (ε2, ε3, ε4), eNOS-VNTR (4,5) and LEP G2548A[4-7]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.