The 15-LOX enzyme is essential in the conversion of the essential omega-3 fatty acid docosahexaenoic acid (DHA) into the potent neuroprotectin D1 (NPD1), and deficits in 15-LOX correlate with NPD1 deficits in AD brain and other human tissues (Lukiw et al., 2005; Hennig et al., 2007; Zhao et al., 2011; Chen et al., 2012). The gene discussed is ALOX15; the disease is Alzheimer disease.