In line with these ideas, CFH is a key negative regulator of the innate immune and complement system, and miRNA-9, miRNA-146a, and miRNA-155 up-regulation is associated with decreased CFH in the neuro-degeneration associated with AD, prion disease, and temporal lobe epilepsy (Lukiw et al., 2008; Hébert and De Strooper, 2009; Perron and Provost, 2009; Aronica et al., 2010; Li et al., 2010; Saba et al., 2012). The gene discussed is CFH; the disease is prion disease.