Although we cannot exclude the contribution to AD pathology of other human brain miRNAs, the inducible, NF-kB-regulated miRNAs miRNA-9, miRNA-125b, miRNA-146a, and miRNA-155 show some of the most significant up-regulated changes in all AD brains so far examined (N = 72; Lukiw et al., 2008; Cui et al., 2010a; Lukiw, 2012b). The gene discussed is NFKB1; the disease is Alzheimer disease.