To cite just one example, pre-miRNA-146a, an inducible, NF-κB-regulated gene, has been associated with the development and propagation of prion disease, epileptogenesis, viral infection, neuro-degeneration, and the induction of neuro-inflammatory signaling and altered innate immune responses in primary human neural cell culture models of AD (Lukiw, 2007b, 2008; Perron and Provost, 2009; Sethi and Lukiw, 2009; Ashe and Zahs, 2010; Lukiw et al., 2010). Here, NFKB1 is linked to prion disease.