SYN2 and Alzheimer disease: The neuronal-enriched phosphoprotein SYN-2 that associates with the cytoplasmic surface of synaptic vesicles is also a miRNA-125b target, and miRNA-125b up-regulation also correlates with SYN-2 down-regulation in AD brain (Yao et al., 2003; Lukiw and Alexandrov, 2012).