The 15-LOX enzyme is essential in the conversion of the essential omega-3 fatty acid DHA into the potent docosanoid neuroprotectin D1 (NPD1), and deficits in 15-LOX significantly correlate with NPD1 deficits in AD brain (Lukiw et al., 2005; Hennig et al., 2007; Zhao et al., 2011). Here, ALOX15 is linked to Alzheimer disease.