A strong positive correlation between miRNA-125b abundance and the glial cell markers glial fibrillary acidic protein (GFAP) and vimentin, and CDKN2A down-regulation is apparent in advanced AD and in DS brain; both of these chronic neurological disorders are typified by a progressive astrogliosis (Pogue et al., 2010; Lukiw and Alexandrov, 2012). This evidence concerns the gene CDKN2A and Alzheimer disease.