Therefore, the integrated miRNA-mRNA interactions of as few as two induced human brain miRNAs – miRNA-125b and miRNA-146a – may in part explain not only the observed down-regulation of CDKN2A, SYN-2, 15-LOX, CFH, IRAK-1, and TSPAN12 expression but may also contribute to pathogenic deficiencies linked with astrogliosis, synaptogenesis, neurotrophic support, innate immune and inflammatory signaling, and amyloidogenesis in the core mechanism of the AD process. This evidence concerns the gene IRAK1 and Alzheimer disease.