BACE1 and Alzheimer disease: miR-107 is enriched in neurons and recent studies indicate that numerous members of miR-15/107 family having the target sites in BACE1 gene including miR-15a, miR-15b, mR-16, miR-195, miR-103 as well as miR-107; all of these miRNAs are down-regulated in gray matter of AD patients (Wang et al., 2011).