It has been proposed that Panx1 channels are involved in pathways activated upon a strong stimulus, such as inflammation (Kanneganti et al., 2007; Silverman et al., 2009), ischemia (Thompson et al., 2006), or myocardial infarction (Dolmatova et al., 2012). The gene discussed is PANX1; the disease is myocardial infarction.