HMGB1 and acute respiratory distress syndrome: Three of these markers, miR-122, HMGB1, and necrosis K18 performed with high AUC values (sensitivity at 90% specificity, 95% CI, P < 0.0001); 0.93 (0.83, 0.86-1.0, P < 0.0001), 0.97 (0.91, 0.91-1.0, P < 0.0001), and 0.94 (0.90, 0.87-1.0, P < 0.0001), respectively, suggesting that these markers could provide the greatest separation between patients with and without ALI at a time when serum ALT activity was normal.