ACHE and attention deficit-hyperactivity disorder: Improvement of ADHD symptoms has been reported in adults and youths treated with cholinergic enhancers, such as Ach partial agonists (e.g. ABT-089) and acetylcholinesterase (AChE) inhibitors (e.g. donepezil) (Doyle et al. 2006; Wilens et al. 2006), although results are inconclusive (Cubo et al. 2008).