Here, we show that SFN, isothiocyanate present in edible plants, targets the pro-survival pathway in breast cancer cells in at least two levels: Akt activation, determined as a drop in phosphorylation in the position crucial for the kinase activity, and mTOR-S6K1 signaling, determined as a decrease in S6K1 phosphorylation in the position recognized by mTOR (Fig. 4). Here, RPS6KB1 is linked to breast carcinoma.