IGFBP7 and acute kidney injury: Risk of AKI (KDIGO stage 2 to 3 within 12 hours) and MAKE30 elevated sharply for [TIMP-2]·[IGFBP7] above 0.3 and almost quintupled and doubled, respectively, for [TIMP-2]·[IGFBP7] above 2.0 (Figure 4).