The identification of mutations in CUL3 and KLHL3 that cause Gordon's syndrome suggested thatthis CUL3–KLHL3 ubiquitin ligase complex plays a critical role in regulating blood pressure.We have now demonstrated that CUL3 and KLHL3 indeed interact to form a functional CRL E3 complex.Importantly, we found that in addition to CUL3, KLHL3 also interacts with the WNK1 and WNK4 isoformsmutated in patients with Gordon's syndrome [1]. This evidence concerns the gene IL31RA and Gordon syndrome.