Referring to frequent mutations in human CRC, the rat cell line CC531 is also known to display a prototypic beta-catenin (Ctnnb1) mutation (Thr(41)Ile) as well as a ki-ras (G12D) mutation, providing unambiguous evidence of the constitutive activation of these pathways [12]. Here, CTNNB1 is linked to colorectal carcinoma.