In conclusion, our results revealed that the cases with Ki67 LI-high and p53 positive showed a mixed tendency towards the “HER2” and “basal” types ,and that a simple immunohistochemical panel comprising Ki67 and p53 could distinguish between the cases with a favorable phenotype group and those with an unfavorable phenotype group among HR-positive and HER2-negative breast cancer patients. The gene discussed is TP53; the disease is breast cancer.