The results of the immunohistochemical panel divided the HR-positive and HER2-negative breast cancer patients as follows: the 10-year DFS rates were 81% for the favorable phenotype group and 46% for the unfavorable phenotype group, while the 10-year OS rates were 97% and 65% for the favorable and unfavorable phenotype groups, respectively. This evidence concerns the gene ERBB2 and breast cancer.