Lubin and co-authors [10] and Trivers and co-authors [11] found that serum p53Abs can be detected in ex-smokers and current smokers even 15 months before the diagnosis of lung, breast, and prostate cancers, suggesting that serum p53Abs, closely associated with p53 mutations, may be useful in the early diagnosis of tobacco-related cancers. This evidence concerns the gene TP53 and prostate cancer.