SPARC expression in every cell population of CML patients at diagnosis was lower than HC (lymphoid cells: 12 fold; monocytes: 9 fold; granulocytes: 2 fold), while after 3 months of IM treatment an increase of SPARC mRNA was found in all cell sub-populations (lymphoid cells: 6 fold; monocytes: 16 fold; granulocytes: 57 fold compared to HC cell subsets), (diagnosis vs treatment: p<0.01 in lymphoid cells and monocytes; p<0.001 in granulocytes). The gene discussed is SPARC; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.