The presence of cerebral malaria was not related to the plasma concentrations of Ang-1, Ang-2 and Tie-2; however, patients with “pure” cerebral malaria (cerebral malaria patients without the other complications of severe malaria according to WHO 2000 criteria) had significantly lower Ang-2 concentration and Ang-2/Ang-1 ratio than the other patients (Table 1). The gene discussed is ANGPT1; the disease is malaria.