ANGPT2 and malaria: As the various clinical manifestations and laboratory parameters of severe malaria are interlinked, a backward stepwise multivariable linear regression model was constructed to determine the factors contributing to plasma Ang-2 level, with plasma level of Ang-2 as the dependent variable and haematocrit, parasite count, platelets, white cell counts, creatinine, SGOT, and lactate as possible explanatory factors.