Because the circulating levels of Ang-1, Ang-2 and Ang-2/Ang-1 ratio have been reported to be clinically informative biomarkers for CM, we examined the expression patterns of proteins Ang-1, Ang-2 and their receptor Tie-2 in the brain tissue of patients dying of CM and compared them to NCM. This evidence concerns the gene ANGPT2 and cutaneous mastocytosis.