TP53 and neoplasm: Vimentin is believed to contribute to recombinational repair of nuclear and mitochondrial DNA [69] and, in line with these observations, this cytoskeletal protein may participate in cytoplasmic anchorage of p53 during senescence [15], thus making it unavailable for its transcriptional targets and, as a consequence, limiting its nuclear-dependent tumor suppressor functions and downstream pathways of cell death and/or cell cycle arrest.