Although the mechanisms by which EGF induced the expression of IL-11 to correlate with physiological functions remain to be determined, the EGF-induced secretion of IL-1β may occur through the autocrine circuit to activate the IL-1 receptor, resulting in the secretion of IL-8 or other secondary cytokines that promote tumor cell survival and invasion [34]. The gene discussed is CXCL8; the disease is neoplasm.