This study reveals a novel mechanism by which bortezomib induces autophagy in HCC cells (i.e., the CIP2A-PP2A-Akt-4EBP1 pathway), and increases understanding of oncogenic proteins such as Ras, Akt and ERK that regulate autophagy [6], [41]. This evidence concerns the gene EIF4EBP1 and hepatocellular carcinoma.