These results show that expression of extracellular matrix genes COL3A1, COL5A1, COL11A1 and FN1 are significantly increased in muscle-invasive bladder tumors relative to Ta/T1 (p<0.05), while changes in CDC25C, MAPK10 and ErbB3 expression approached significance (p≤0.08) (Table 4). The gene discussed is ERBB3; the disease is urinary bladder neoplasm.