CEBPA has gained interest in the AML field, as it has been shown that down-regulation of CEBPA protein through mutations, posttranscriptional modifications and protein-protein interactions with fusion proteins such as RUNX1-RUNX1T1 or CBFB-MYH11 plays a key role in leukemic transformation. The gene discussed is CEBPA; the disease is acute myeloid leukemia.