To better understand the immune status in CML and to compare the immune status of HR and LR patients, samples from newly diagnosed patients were investigated for the presence of MDSCs, Arg-1, PD-L1/PD-1, as well as sCD25, all important regulators of T cell anti-tumor immunity. The gene discussed is CD274; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.