PLAU and neoplasm: Ets1, a member of the ETS family of transcription factors, binds to specific DNA sequences containing a GGAA/T core motif [22], and participates in tumor invasion and metastasis through transcriptional regulation of several genes responsible for extracellular matrix remodeling, migration, and invasion, such as matrix metalloproteinase and urokinase plasminogen activator [22].