The immunoreactivity of cyclin D1 and Ets1 was significantly higher in gastric cancer cases with deeper gastric wall invasion (P<0.001 and P = 0.001), lymph node metastasis (P<0.001 and P<0.001), distant metastasis (P<0.001 and P<0.001), and advanced TNM stage (P<0.001 and P = 0.004) (Table S1). The gene discussed is ETS1; the disease is gastric cancer.