MMP8 and chronic obstructive pulmonary disease: This leads to the conclusion that the increase in MMP9 levels in COPD patients is the result of an increase in neutrophil number and not due to an increase in MMP9 release.Besides MMP8 and MMP9, PE is needed to generate PGP from whole collagen; the MMPs cleave whole collagen in fragments of 30 to 100 amino acids in length, after which PE specifically cleaves PGP from these smaller fragments [9].