CCN2 and glioblastoma: In order to investigate if normal embryonic or neonatal rat neurons could modulate the expression of CTGF in GBM cells, as occurred with laminin on this GBM [36], we co-cultured E18 and P0 onto GBM95, GBM02 or U87 cell carpets and performed double immunocytochemistry with anti-CTGF antibody and anti-β tubulin III (Fig. 2).