Levels of IL-8 were higher in CLI patients with diabetes compared to non-diabetic patients (18.7 [13.4–25.2] pg/ml vs 14.3 [9.9–22.5] pg/ml, P = 0.048) and IL-6 levels showed a similar trend (10.5 [3.9–15.3] pg/ml vs 4.5 [1.4–11.2] pg/ml, P = 0.050). This evidence concerns the gene CXCL8 and diabetes mellitus.